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J Cancer Res Clin Oncol. 2012 Apr;138(4):671-4. doi: 10.1007/s00432-012-1147-9. Epub 2012 Jan 12.

Circulating microRNA-218 was reduced in cervical cancer and correlated with tumor invasion.

Author information

1
Department of Obstetrics and Gynecology, The Fourth Affiliated Hospital of Suzhou University, Huihe Road No. 200, Binhu District, Wuxi 214062, People's Republic of China. wxsyyujj@gmail.com

Abstract

BACKGROUNDS:

microRNA-218 was proved to be a tumor-suppressor microRNA in several cancers, but its status in cervical cancer patients has not been established. In this study, we investigated the expression of microRNA-218 in the sera from cervical cancer patients and its relationships with clinico-pathological characteristics.

METHODS:

The expression of microRNA-218 was detected in the sera of 90 cervical cancer patients and 50 normal age-matched women by quantitative real-time PCR. The clinical data were collected and analyzed by statistical software.

RESULTS:

In the cancer group, microRNA-218 was reduced significantly in the sera (P < 0.001). Moreover, decreased microRNA-218 was associated with later stages, cervical adenocarcinoma, and lymphatic node metastasis.

CONCLUSIONS:

microRNA-218 was deregulated in most cervical cancer patients and associated with tumor invasion.

PMID:
22237456
DOI:
10.1007/s00432-012-1147-9
[Indexed for MEDLINE]

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