Spontaneous abortion is one of the most common gestational conditions, with the morbidity of 1% to 5% in married women. It is a serious problem troubling women at the reproductive age. There are many factors causing spontaneous abortion, among them, spontaneous abortion resulting from endocrine abnormalities can be detected and treated. Prolactin is a major endocrine hormone participating in reproductive regulation and playing an important role in early pregnancy implantation and pregnancy maintenance. When there are unusual levels it is closely related to spontaneous abortion, leading to a necessity to further study the relationship between them. International and domestic research developments in recent years about the correlation between prolactin and spontaneous abortion are discussed in this paper.