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Cell Death Dis. 2012 Jan 12;3:e247. doi: 10.1038/cddis.2011.122.

Role of the promyelocytic leukaemia protein in cell death regulation.

Author information

1
Samantha Dickson Brain Cancer Unit, UCL Cancer Institute, 72 Huntley Street, London WC1E 6BT, UK. p.salomoni@cancer.ucl.ac.uk

Abstract

The promyelocytic leukaemia gene PML was originally identified at the t(15;17) translocation of acute promyelocytic leukaemia, which generates the oncogene PML-retinoic acid receptor α. PML epitomises a subnuclear structure called PML nuclear body. Current models propose that PML through its scaffold properties is able to control cell growth and survival at many different levels. Here we discuss the current literature and propose new avenues for investigation.

PMID:
22237204
PMCID:
PMC3270264
DOI:
10.1038/cddis.2011.122
[Indexed for MEDLINE]
Free PMC Article

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