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PLoS One. 2012;7(1):e29151. doi: 10.1371/journal.pone.0029151. Epub 2012 Jan 3.

Estimating diarrhea mortality among young children in low and middle income countries.

Author information

1
Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America. cfischer@jhsph.edu

Abstract

BACKGROUND:

Diarrhea remains one of the leading causes of morbidity and mortality among children under 5 years of age, but in many low and middle-income countries where vital registration data are lacking, updated estimates with regard to the proportion of deaths attributable to diarrhea are needed.

METHODS:

We conducted a systematic literature review to identify studies reporting diarrhea proportionate mortality for children 1-59 mo of age published between 1980 and 2009. Using the published proportionate mortality estimates and country level covariates we constructed a logistic regression model to estimate country and regional level proportionate mortality and estimated uncertainty bounds using Monte-Carlo simulations.

FINDINGS:

We identified more than 90 verbal autopsy studies from around the world to contribute data to a single-cause model. We estimated diarrhea proportionate mortality for 84 countries in 6 regions and found diarrhea to account for between 10.0% of deaths in the Americas to 31.3% of deaths in the South-east Asian region.

DISCUSSION:

Diarrhea remains a leading cause of death for children 1-59 mo of age. Published literature can be used to create a single-cause mortality disease model to estimate mortality for countries lacking vital registration data.

PMID:
22235266
PMCID:
PMC3250411
DOI:
10.1371/journal.pone.0029151
[Indexed for MEDLINE]
Free PMC Article
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