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Oncologist. 2012;17(1):46-54. doi: 10.1634/theoncologist.2011-0227. Epub 2012 Jan 10.

Sarcomatoid renal cell carcinoma: a comprehensive review of the biology and current treatment strategies.

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1
Urologic Oncology Branch, National Cancer Institute, National Institutes of Health, 10 Center Drive MSC 1107, Building 10, CRC, Room 1-5940, Bethesda, Maryland 20892-1107, USA.

Abstract

Recent advancements in the molecular characterization of renal cell carcinoma altered the classification system and now kidney cancer is divided into several distinct histologic subtypes. Although once a separate histologic category, sarcomatoid renal cell carcinoma is no longer considered a separate tumor type because it can occur with all histologic subtypes. Limited research on tumors with sarcomatoid change has led to minimal progress in the understanding and treatment of these tumors. Because the sarcomatoid variant of renal cell carcinoma can account for approximately one in six cases of advanced kidney cancer, we hope to familiarize clinicians with these tumors by describing the historic background, histologic features, molecular characterization, diagnosis, prognosis, treatment strategies, and active clinical trials of this aggressive type of tumor.

PMID:
22234634
PMCID:
PMC3267822
DOI:
10.1634/theoncologist.2011-0227
[Indexed for MEDLINE]
Free PMC Article
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