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Biochim Biophys Acta. 2012 Aug;1821(8):1068-77. doi: 10.1016/j.bbalip.2011.12.007. Epub 2011 Dec 31.

Phospholipid flippases: building asymmetric membranes and transport vesicles.

Author information

1
Department of Biological Sciences, Vanderbilt University, Nashville TN 37235, USA.

Abstract

Phospholipid flippases in the type IV P-type ATPase family (P4-ATPases) are essential components of the Golgi, plasma membrane and endosomal system that play critical roles in membrane biogenesis. These pumps flip phospholipid across the bilayer to create an asymmetric membrane structure with substrate phospholipids, such as phosphatidylserine and phosphatidylethanolamine, enriched within the cytosolic leaflet. The P4-ATPases also help form transport vesicles that bud from Golgi and endosomal membranes, thereby impacting the sorting and localization of many different proteins in the secretory and endocytic pathways. At the organismal level, P4-ATPase deficiencies are linked to liver disease, obesity, diabetes, hearing loss, neurological deficits, immune deficiency and reduced fertility. Here, we review the biochemical, cellular and physiological functions of P4-ATPases, with an emphasis on their roles in vesicle-mediated protein transport. This article is part of a Special Issue entitled Lipids and Vesicular Transport.

PMID:
22234261
PMCID:
PMC3368091
DOI:
10.1016/j.bbalip.2011.12.007
[Indexed for MEDLINE]
Free PMC Article

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