Format

Send to

Choose Destination
See comment in PubMed Commons below
Expert Opin Ther Targets. 2012 Feb;16(2):167-78. doi: 10.1517/14728222.2012.648926. Epub 2012 Jan 10.

SIRT1: new avenues of discovery for disorders of oxidative stress.

Author information

1
University of Medicine and Dentistry - New Jersey Medical School, Laboratory of Cellular and Molecular Signaling, Newark, NJ 07101, USA.

Abstract

INTRODUCTION:

The sirtuin SIRT1 is expressed throughout the body, has broad biological effects and can significantly affect both cellular survival and longevity during acute and long-term injuries, which involve both oxidative stress and cell metabolism.

AREAS COVERED:

SIRT1 has an intricate role in the pathology, progression, and treatment of several disease entities, including neurodegenerative disorders such as Alzheimer's disease and Parkinson's disease, tumorigenesis, cardiovascular disease with myocardial injury and atherosclerosis, metabolic disease, and aging-related disease. New areas of study in these disciplines, with discussion of the cellular biology, are highlighted.

EXPERT OPINION:

Novel signaling pathways for SIRT1, which can be targeted to enhance cellular protection and potentially extend lifespan, continue to emerge. Investigations that can further determine the intracellular signaling, trafficking and post-translational modifications that occur with SIRT1 in a variety of cell systems and environments will allow us to further translate this knowledge into effective therapeutic strategies that will be applicable to multiple systems of the body.

PMID:
22233091
PMCID:
PMC3279588
DOI:
10.1517/14728222.2012.648926
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Taylor & Francis Icon for PubMed Central
    Loading ...
    Support Center