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J Neural Transm (Vienna). 2012 Jun;119(6):697-9. doi: 10.1007/s00702-011-0761-z. Epub 2012 Jan 10.

Development of Parkinson's disease in patients with Narcolepsy.

Author information

1
Department of Neurology, University of California, San Francisco, 400 Parnassus Avenue, Box 0348, San Francisco, CA 94143, USA. Chad.Christine@ucsf.edu

Abstract

Although amphetamine drugs can damage dopaminergic axons, it is unknown whether chronic treatment with amphetamine increases the risk of developing Parkinson's disease (PD). Of 1,152 consecutive PD patients, 3 had a prior diagnosis of narcolepsy. This rate is five times higher than expected (p = 0.02). These patients had typical onset of narcolepsy and underwent treatment with amphetamine. Although preliminary, this observation raises the possibility that some factors intrinsic to narcolepsy or its treatment may be a risk factor for PD.

PMID:
22231845
DOI:
10.1007/s00702-011-0761-z
[Indexed for MEDLINE]

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