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Methods Mol Biol. 2012;829:243-56. doi: 10.1007/978-1-61779-458-2_15.

Modeling nicotine addiction in rats.

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CNRS UMR 5287, "Neuropsychopharmacology of Addiction" Group, University of Bordeaux, Bordeaux, France.


Among the human population, 15% of drug users develop a pathological drug addiction. This figure increases substantially with nicotine, whereby more than 30% of those who try smoking develop a nicotine addiction. Drug addiction is characterized by compulsive drug-seeking and drug-taking behaviors (craving), and loss of control over intake despite impairment in health, social, and occupational functions. This behavior can be accurately modeled in the rat using an intravenous self-administration (IVSA) paradigm. Initial attempts at establishing nicotine self-administration had been problematic, yet in recent times increasingly reliable models of nicotine self-administration have been developed. The present article reviews different characteristics of the nicotine IVSA model that has been developed to examine nicotine reinforcing and motivational properties in rats.

[Indexed for MEDLINE]

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