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J Neuropsychiatry Clin Neurosci. 2011 Fall;23(4):434-41. doi: 10.1176/appi.neuropsych.23.4.434.

Incidence, course, and predictors of apathy in Huntington's disease: a two-year prospective study.

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  • 1Department of Psychiatry, Leiden University Medical Center, The Netherlands.


This study examined the incidence and course of apathy in subjects with Huntington's disease (HD). Our results showed that at follow-up 14% of the subjects free of apathy at baseline had developed apathy. In these subjects, a lower baseline Mini-Mental State Exam score predicted incidence of apathy. Of the 34 subjects with apathy at baseline, 14 subjects were no longer apathetic at follow-up. Twenty subjects had persistent apathy, with a low baseline Symbol Digits Modalities Test as the only predictor. These results showed that apathy in HD is most closely linked to global and executive cognitive performance.

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