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J Neuropsychiatry Clin Neurosci. 2011 Fall;23(4):391-8. doi: 10.1176/jnp.23.4.jnp391.

Neurocognitive functioning in youth with pediatric autoimmune neuropsychiatric disorders associated with streptococcus.

Author information

1
University of South Florida College of Medicine, Department of Pediatrics, Rothman Center for Neuropsychiatry, USA. alewin@health.usf.edu

Abstract

This study evaluated neurocognitive functioning in 26 youth with Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal infections (PANDAS) and primarily obsessive-compulsive disorder (OCD) symptoms. Marked impairment in visuospatial recall memory (as assessed using the Rey-Osterrieth Complex Figure Test) was observed in spite of average to above-average performance on academic and other neurocognitive measures. Group A beta-hemolytic Streptococcus titer elevations were associated with worse performance on tasks of neurocognitive and executive ability (Stroop Color-Word Interference Test), visuospatial memory, and fine motor speed (finger tapping) as well as elevated obsessive-compulsive symptom severity.

PMID:
22231309
DOI:
10.1176/jnp.23.4.jnp391
[Indexed for MEDLINE]

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