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Dev Biol. 2012 Jun 1;366(1):2-9. doi: 10.1016/j.ydbio.2011.12.042. Epub 2012 Jan 2.

Development and evolution of the neural crest: an overview.

Author information

1
California Institute of Technology MC 139-74 Pasadena, CA 91125, USA. mebronner@gmail.com

Abstract

The neural crest is a multipotent and migratory cell type that forms transiently in the developing vertebrate embryo. These cells emerge from the central nervous system, migrate extensively and give rise to diverse cell lineages including melanocytes, craniofacial cartilage and bone, peripheral and enteric neurons and glia, and smooth muscle. A vertebrate innovation, the gene regulatory network underlying neural crest formation appears to be highly conserved, even to the base of vertebrates. Here, we present an overview of important concepts in the neural crest field dating from its discovery 150 years ago to open questions that will motivate future research.

PMID:
22230617
PMCID:
PMC3351559
DOI:
10.1016/j.ydbio.2011.12.042
[Indexed for MEDLINE]
Free PMC Article

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