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Public Health Nutr. 2012 Jul;15(7):1291-8. doi: 10.1017/S1368980011003284. Epub 2012 Jan 10.

Serum ferritin levels associated with increased risk for developing CHD in a low-income urban population.

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1
U.S. Department of Agriculture Food Surveys Research Group, Beltsville, MD, USA.

Erratum in

  • Public Health Nutr. 2012 Jun;15(6):1138.

Abstract

OBJECTIVE:

The present study examined the association of serum ferritin with CHD risk using the Framingham Heart Study's 10-year risk algorithm.

DESIGN:

Ordinal logistic regression modelling was used to interpret risk. Proportional odds modelling assessed four divisions of ranked CHD risk (4, high; 3, increased; 2, slight; 1, minimal), separately by sex.

SETTING:

Baltimore, MD, USA.

SUBJECTS:

African-American and white participants (n 1823) from baseline of the Healthy Aging in Neighborhoods of Diversity across the Life Span (HANDLS) study, aged 30-64 years.

RESULTS:

For men, there was a 0·5 % increase in risk for every 10-unit rise in serum ferritin (pmol/l). Other significant predictors included increased BMI, white race, unemployment and C-reactive protein ≥9·5 mg/l. For women, there was a 1·5 % [corrected] increase in risk per 10-unit rise in serum ferritin (pmol/l). Other significant predictors included increased BMI, lower education, unemployment and C-reactive protein ≥9·5 mg/l.

CONCLUSIONS:

Serum ferritin is a significant predictor of 10-year hard CHD risk for HANDLS study participants, a low-income, urban population. Serum ferritin, independent of elevated C-reactive protein, was associated with increased 10-year CHD risk for HANDLS participants. To our knowledge, these data provide the first evidence of the role of serum ferritin as a risk factor for hard CHD in African-American and white postmenopausal women in the USA. Future research on cardiovascular events from this prospective study may confirm the association.

PMID:
22230289
PMCID:
PMC3445714
DOI:
10.1017/S1368980011003284
[Indexed for MEDLINE]
Free PMC Article
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