Format

Send to

Choose Destination
See comment in PubMed Commons below
ACS Nano. 2012 Feb 28;6(2):1260-7. doi: 10.1021/nn203895n. Epub 2012 Jan 20.

Photoacoustic sentinel lymph node imaging with self-assembled copper neodecanoate nanoparticles.

Author information

1
C-TRAIN and Division of Cardiology, Washington University School of Medicine, 4320 Forest Park Avenue, St. Louis, Missouri 63108, United States. dipanjan@wustl.edu

Abstract

Photoacoustic tomography (PAT) is emerging as a novel, hybrid, and non-ionizing imaging modality because of its satisfactory spatial resolution and high soft tissue contrast. PAT combines the advantages of both optical and ultrasonic imaging methods. It opens up the possibilities for noninvasive staging of breast cancer and may replace sentinel lymph node (SLN) biopsy in clinic in the near future. In this work, we demonstrate for the first time that copper can be used as a contrast metal for near-infrared detection of SLN using PAT. A unique strategy is adopted to encapsulate multiple copies of Cu as organically soluble small molecule complexes within a phospholipid-entrapped nanoparticle. The nanoparticles assumed a size of 80-90 nm, which is the optimum hydrodynamic diameter for its distribution throughout the lymphatic systems. These particles provided at least 6-fold higher signal sensitivity in comparison to blood, which is a natural absorber of light. We also demonstrated that high SLN detection sensitivity with PAT can be achieved in a rodent model. This work clearly demonstrates for the first time the potential use of copper as an optical contrast agent.

PMID:
22229462
PMCID:
PMC3289744
DOI:
10.1021/nn203895n
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for American Chemical Society Icon for PubMed Central
    Loading ...
    Support Center