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Int J Nanomedicine. 2011;6:3251-7. doi: 10.2147/IJN.S25449. Epub 2011 Dec 12.

Grafting of a novel gold(III) complex on nanoporous MCM-41 and evaluation of its toxicity in Saccharomyces cerevisiae.

Author information

1
Department of Chemistry, Faculty of Sciences, Shahid Beheshti University, Evin, Tehran, Iran.

Abstract

The goal of this research was to investigate the potential of newly synthesized gold complex trichloro(2,4,6-trimethylpyridine)Au(III) as an anticancer agent. The gold(III) complex was synthesized and grafted on nanoporous silica, MCM-41, to produce AuCl(3)@PF-MCM- 41 (AuCl(3) grafted on pyridine-functionalized MCM-41). The toxicity of trichloro(2,4,6- trimethylpyridine)Au(III) and AuCl(3)@PF-MCM-41 in Saccharomyces cerevisiae (as a model system) was studied. The gold(III) complex showed a mid cytotoxic effect on yeast viability. Using the drug delivery system, nanoporous MCM-41, the gold(III) complex became a strong inhibitor for growth of yeast cells at a very low concentration. Furthermore, the animal tests revealed a high uptake of AuCl(3)@PF-MCM-41 in tumor cells. The stability of the compound was confirmed in human serum.

KEYWORDS:

Au(III); MCM-41; Saccharomyces cerevisiae; anticancer agent; trichloro(2,4,6-trimethylpyridine)Au(III)

PMID:
22228993
PMCID:
PMC3252673
DOI:
10.2147/IJN.S25449
[Indexed for MEDLINE]
Free PMC Article

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