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Diabetes Care. 2012 Mar;35(3):624-6. doi: 10.2337/dc11-1773. Epub 2012 Jan 6.

Potential implications of coronary artery calcium testing for guiding aspirin use among asymptomatic individuals with diabetes.

Author information

1
Johns Hopkins Ciccarone Center for the Prevention of Heart Disease, Baltimore, Maryland, USA.

Abstract

OBJECTIVE:

It is unclear whether coronary artery calcium (CAC) is effective for risk stratifying patients with diabetes in whom treatment decisions are uncertain.

RESEARCH DESIGN AND METHODS:

Of 44,052 asymptomatic individuals referred for CAC testing, we studied 2,384 individuals with diabetes. Subjects were followed for a mean of 5.6 ± 2.6 years for the end point of all-cause mortality.

RESULTS:

There were 162 deaths (6.8%) in the population. CAC was a strong predictor of mortality across age-groups (age <50, 50-59, ≥60), sex, and risk factor burden (0 vs. ≥1 additional risk factor). In individuals without a clear indication for aspirin per current guidelines, CAC stratified risk, identifying patients above and below the 10% risk threshold of presumed aspirin benefit.

CONCLUSIONS:

CAC can help risk stratify individuals with diabetes and may aid in selection of patients who may benefit from therapies such as low-dose aspirin for primary prevention.

PMID:
22228745
PMCID:
PMC3322717
DOI:
10.2337/dc11-1773
[Indexed for MEDLINE]
Free PMC Article

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