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Clin Immunol. 2012 Mar;142(3):343-50. doi: 10.1016/j.clim.2011.12.001. Epub 2011 Dec 16.

Thymic function after allogeneic stem cell transplantation is dependent on graft source and predictive of long term survival.

Author information

1
Center for Allogeneic Stem Cell Transplantation, B87, Karolinska University Hospital, SE-141 86 Stockholm, Sweden. darius.sairafi@ki.se

Abstract

T-cell deficiency after allogeneic stem cell transplantation (ASCT) is common and has major impact on clinical outcome. In this retrospective study 210 patients were analyzed with regards to levels of T-cell receptor excision circles (TRECs) during the first 24 months after transplantation. We could for the first time show a significant correlation between the use of bone marrow grafts and higher TREC levels >6 months post-ASCT (p<0.001). Treatment with anti-thymocyte globulin was correlated with lower TREC levels ≤6 months post-ASCT (p<0.001). Patients with TREC levels above median at 3 months had a superior overall survival, 80% vs. 56% (p=0.002), and lower transplantation-related mortality, 7% vs. 21% (p=0.01). We conclude that graft source and conditioning regimen may have a significant effect on T-cell reconstitution after ASCT and can thus affect outcome. These results strongly support the use of TREC measurement as part of the standard repertoire of immunological monitoring after ASCT.

PMID:
22227522
DOI:
10.1016/j.clim.2011.12.001
[Indexed for MEDLINE]

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