Format

Send to

Choose Destination
See comment in PubMed Commons below
Neuroimage. 2012 Mar;60(1):370-5. doi: 10.1016/j.neuroimage.2011.12.044. Epub 2011 Dec 28.

Cortico-subthalamic white matter tract strength predicts interindividual efficacy in stopping a motor response.

Author information

1
Cognitive Science Center Amsterdam, University of Amsterdam, Amsterdam, The Netherlands. b.u.forstmann@uva.nl

Abstract

The subthalamic nucleus (STN) is a small but vitally important structure in the basal ganglia. Because of its small volume, and its localization in the basal ganglia, the STN can best be visualized using ultra-high resolution 7 Tesla (T) magnetic resonance imaging (MRI). In the present study, first we individually segmented 7 T MRI STN masks to generate atlas probability maps. Secondly, the individually segmented STN masks and the probability maps were used to derive cortico-subthalamic white matter tract strength. Tract strength measures were then taken to test two functional STN hypotheses which account for the efficiency in stopping a motor response: the right inferior fronto-subthalamic (rIFC-STN) hypothesis and the posterior medial frontal cortex-subthalamic (pMFC-STN) hypothesis. Results of two independent experiments show that increased white matter tract strength between the pMFC and STN results in better stopping behaviour.

[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center