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Cell Metab. 2012 Jan 4;15(1):4-5. doi: 10.1016/j.cmet.2011.12.011.

Power surge: supporting cells "fuel" cancer cell mitochondria.

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1
The Jefferson Stem Cell Biology and Regenerative Medicine Center, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA.

Abstract

An emerging paradigm in tumor metabolism is that catabolism in host cells "fuels" the anabolic growth of cancer cells via energy transfer. A study in Nature Medicine (Nieman et al., 2011) supports this; they show that triglyceride catabolism in adipocytes drives ovarian cancer metastasis by providing fatty acids as mitochondrial fuels.

PMID:
22225869
DOI:
10.1016/j.cmet.2011.12.011
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