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Reproduction. 2012 Mar;143(3):231-46. doi: 10.1530/REP-11-0374. Epub 2012 Jan 5.

Trophoblast development.

Author information

1
Reproductive Technologies, AgResearch Crown Research Institute, Hamilton 3204, New Zealand. peter.pfeffer@agresearch.co.nz

Abstract

This review summarises current knowledge about the specification, commitment and maintenance of the trophoblast lineage in mice and cattle. Results from gene expression studies, in vivo loss-of-function models and in vitro systems using trophoblast and embryonic stem cells have been assimilated into a model seeking to explain trophoblast ontogeny via gene regulatory networks. While trophoblast differentiation is quite distinct between cattle and mice, as would be expected from their different modes of implantation, recent studies have demonstrated that differences arise much earlier during trophoblast development.

PMID:
22223687
DOI:
10.1530/REP-11-0374
[Indexed for MEDLINE]

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