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Transcription. 2011 Nov-Dec;2(6):254-7. doi: 10.4161/trns.2.6.18076. Epub 2011 Nov 1.

Revealing the functions of TFIIB.

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  • 1Department of Life Sciences, Imperial College London, London, UK.

Abstract

The TFIIB linker domain stimulates the catalytic activity of archaeal RNAP. By characterising a range of super-stimulating mutants we identified a novel rate-limiting step in transcription initiation. Our results help to interpret structural findings and pave the way towards higher-resolution structures of the RNAP-TFIIB linker interface.

PMID:
22223047
PMCID:
PMC3265785
DOI:
10.4161/trns.2.6.18076
[PubMed - indexed for MEDLINE]
Free PMC Article
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