Format

Send to

Choose Destination
Trends Neurosci. 2012 Feb;35(2):135-43. doi: 10.1016/j.tins.2011.12.002. Epub 2012 Jan 3.

Postsynaptic signaling during plasticity of dendritic spines.

Author information

1
Department of Neurobiology, Duke University Medical Center, Durham, NC 27710, USA.

Abstract

Dendritic spines, small bulbous postsynaptic compartments emanating from neuronal dendrites, have been thought to serve as basic units of memory storage. Despite their small size (~0.1 femtoliter), thousands of species of proteins exist in the spine, including receptors, channels, scaffolding proteins and signaling enzymes. Biochemical signaling mediated by these molecules leads to morphological and functional plasticity of dendritic spines, and ultimately learning and memory in the brain. Here, we review new insights into the mechanisms underlying spine plasticity brought about by recent advances in imaging techniques to monitor molecular events in single dendritic spines. The activity of each protein displays a specific spatiotemporal pattern, coordinating downstream events at different microdomains to change the function and morphology of dendritic spines.

PMID:
22222350
PMCID:
PMC3306839
DOI:
10.1016/j.tins.2011.12.002
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center