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Trends Immunol. 2012 Feb;33(2):84-90. doi: 10.1016/ Epub 2012 Jan 3.

Memory T cell inflation: understanding cause and effect.

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Peter Medawar Building for Pathogen Research, South Parks Road, Oxford OX1 4SY, UK.


Typically, during viral infections, T cells encounter antigen, undergo proliferative expansion and ultimately contract into a pool of memory cells. However, after infection with cytomegalovirus, a ubiquitous β-herpesvirus, T cell populations specific for certain epitopes do not contract but instead are maintained and/or accumulate at high frequencies with a characteristic effector-memory phenotype. This feature has also been noted after other infections, for example, by parvoviruses. We discuss this so-called memory T cell inflation and the factors involved in this phenomenon. Also, we consider the potential therapeutic use of memory T cell inflation as a vaccine strategy and the associated implications for immune senescence.

[Indexed for MEDLINE]

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