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Hum Pathol. 2012 Apr;43(4):467-80. doi: 10.1016/j.humpath.2011.08.024. Epub 2012 Jan 4.

Mantle cell lymphoma as a component of composite lymphoma: clinicopathologic parameters and biologic implications.

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Department of Pathology, Hippokration General Hospital of Thessaloniki, 54642 Thessaloniki, Greece.


Composite lymphoma is a rare circumstance in which 2 or more distinct types of lymphoma occur in a single anatomical location. Although composite lymphoma has been increasingly identified with the advent of molecular genetic techniques, this topic has only rarely been a specific focus of the medical scientific literature. In this review, we focus on mantle cell lymphoma occurring as a major pathologic component of composite lymphoma and emphasize the clinicopathologic features of these tumors and associated biologic implications. To date, 26 cases of composite lymphoma including a component of mantle cell lymphoma have been previously published. Issues of clonal relatedness between the individual lymphoma components and emerging biologic implications as well as potential diagnostic pitfalls are evaluated.

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