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Oral Dis. 2012 May;18(4):389-95. doi: 10.1111/j.1601-0825.2011.01887.x. Epub 2012 Jan 3.

MBL2, MASP2, AMELX, and ENAM gene polymorphisms and dental caries in Polish children.

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1
Department of Hygiene, Epidemiology and Public Health, Pomeranian Medical University, Szczecin, Poland. olsza@sci.pam.szczecin.pl

Abstract

OBJECTIVE:

The aim of the study was to examine whether the MBL2 C(-290)G and G161A, MASP2 A359G, AMELX C287T and C522T, and ENAM C2452T polymorphisms are associated with dental caries.

SUBJECTS AND METHODS:

Genomic DNA of 95 Polish children with 'higher caries experience' (HC) and 84 subjects with 'lower caries experience' (LC) belonging to two age-groups (5 and 13 years old) was extracted from the buccal mucosa. SNPs were genotyped with PCR-RFLP methods.

RESULTS:

Among 5-year-old children, we found significantly higher percentage of subjects carrying MBL2 (-290)G allele in HC group compared with LC group (43.2%vs 17.6%, P = 0.023). MBL2 C(-290)G-G161A C-G haplotype was overrepresented in LC group in 5-year-olds (P = 0.01), while the opposite association was observed in 13-year-olds, where C-G was overrepresented in HC group (P = 0.028). In 5-year-old children, the frequency of MBL2 G-G haplotype was higher in HC group compared with LC subjects (P = 0.045), while the opposite association (with borderline significance) was observed in 13-year-old children (P = 0.057). SNPs in MASP2, AMELX, and ENAM were not associated with dental caries.

CONCLUSION:

MBL2 gene polymorphism is associated with caries experience in Polish children, but the direction of this association seems to be opposite in primary and permanent dentition.

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