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Biochemistry. 2012 Jan 24;51(3):733-5. doi: 10.1021/bi201601k. Epub 2012 Jan 17.

Solution structure of CCL21 and identification of a putative CCR7 binding site.

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  • 1Department of Chemistry, University of Wisconsin-Whitewater, Whitewater, Wisconsin 53190, United States.

Abstract

CCL21 is a human chemokine that recruits normal immune cells and metastasizing tumor cells to lymph nodes through activation of the G protein-coupled receptor CCR7. The CCL21 structure solved by NMR contains a conserved chemokine domain followed by an extended, unstructured C-terminus that is not typical of most other chemokines. A sedimentation equilibrium study showed CCL21 to be monomeric. Chemical shift mapping indicates that the CCR7 N-terminus binds to the N-loop and third β-strand of CCL21's chemokine domain. Details of CCL21-receptor recognition may enable structure-based drug discovery of novel antimetastatic agents.

PMID:
22221265
PMCID:
PMC3272885
DOI:
10.1021/bi201601k
[PubMed - indexed for MEDLINE]
Free PMC Article
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