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Mol Microbiol. 2012 Mar;83(5):879-83. doi: 10.1111/j.1365-2958.2012.07972.x. Epub 2012 Feb 1.

N for AsN - O for strOcture? A strand-loop-strand motif for prokaryotic O-glycosylation.

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Interdisciplinary Nanoscience Center (iNANO), Center for insoluble Protein Structures, Department of Molecular Biology and Genetics, University of Aarhus, Gustav Wieds Vej 10C, Aarhus C, Denmark.


So far, it has not been possible to identify a general sequence motif for O-glycosylation in bacteria. In this issue, Charbonneau et al. (2012) demonstrate why O-glycosylation is mediated by a 13-residue strand-loop-strand motif which is part of a 19-residue imperfect repeat in the passenger domain of bacterial autotransporters. This motif provides a convenient 'glycosylation cassette' and raises intriguing questions about the structural regulation of the glycosylation pathway.

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