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Mol Microbiol. 2012 Mar;83(5):879-83. doi: 10.1111/j.1365-2958.2012.07972.x. Epub 2012 Feb 1.

N for AsN - O for strOcture? A strand-loop-strand motif for prokaryotic O-glycosylation.

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1
Interdisciplinary Nanoscience Center (iNANO), Center for insoluble Protein Structures, Department of Molecular Biology and Genetics, University of Aarhus, Gustav Wieds Vej 10C, Aarhus C, Denmark. dao@inano.au.dk

Abstract

So far, it has not been possible to identify a general sequence motif for O-glycosylation in bacteria. In this issue, Charbonneau et al. (2012) demonstrate why O-glycosylation is mediated by a 13-residue strand-loop-strand motif which is part of a 19-residue imperfect repeat in the passenger domain of bacterial autotransporters. This motif provides a convenient 'glycosylation cassette' and raises intriguing questions about the structural regulation of the glycosylation pathway.

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