Format

Send to

Choose Destination
See comment in PubMed Commons below
J Neurosci. 2012 Jan 4;32(1):254-63. doi: 10.1523/JNEUROSCI.3701-11.2012.

Micro-positron emission tomography imaging of rat brain metabolism during expression of contextual conditioning.

Author information

1
Division of Experimental Neurosurgery and Neuroanatomy, Katholieke Universiteit Leuven, 3000 Leuven, Belgium. laura.luyten@med.kuleuven.be

Abstract

Using (18)F-fluorodeoxyglucose microPET imaging, we investigated the neurocircuitry of contextual anxiety versus control in awake, conditioned rats (n = 7-10 per group). In addition, we imaged a group expressing cued fear. Simultaneous measurements of startle amplitude and freezing time were used to assess conditioning. To the best of our knowledge, no neuroimaging studies in conditioned rats have been conducted thus far, although visualizing and quantifying the metabolism of the intact brain in behaving animals is clearly of interest. In addition, more insight into the neurocircuitry involved in contextual anxiety may stimulate the development of new treatments for anxiety disorders. Our main finding was hypermetabolism in a cluster comprising the bed nucleus of the stria terminalis (BST) in rats expressing contextual anxiety compared with controls. Analysis of a subset of rats showing the best behavioral results (n = 5 per subgroup) confirmed this finding. We also observed hypermetabolism in the same cluster in rats expressing contextual anxiety compared with rats expressing cued fear. Our results provide novel evidence for a role of the BST in the expression of contextual anxiety.

PMID:
22219287
DOI:
10.1523/JNEUROSCI.3701-11.2012
[Indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire
    Loading ...
    Support Center