Format

Send to

Choose Destination
J Invest Dermatol. 2012 Mar;132(3 Pt 2):964-75. doi: 10.1038/jid.2011.425. Epub 2012 Jan 5.

Applications of nanotechnology in dermatology.

Author information

1
Department of Biomedical Engineering, University of Rochester, Rochester, New York 14642, USA. Lisa_DeLouise@urmc.rochester.edu

Abstract

What are nanoparticles and why are they important in dermatology? These questions are addressed by highlighting recent developments in the nanotechnology field that have increased the potential for intentional and unintentional nanoparticle skin exposure. The role of environmental factors in the interaction of nanoparticles with skin and the potential mechanisms by which nanoparticles may influence skin response to environmental factors are discussed. Trends emerging from recent literature suggest that the positive benefit of engineered nanoparticles for use in cosmetics and as tools for understanding skin biology and curing skin disease outweigh potential toxicity concerns. Discoveries reported in this journal are highlighted. This review begins with a general introduction to the field of nanotechnology and nanomedicine. This is followed by a discussion of the current state of understanding of nanoparticle skin penetration and their use in three therapeutic applications. Challenges that must be overcome to derive clinical benefit from the application of nanotechnology to skin are discussed last, providing perspective on the significant opportunity that exists for future studies in investigative dermatology.

PMID:
22217738
PMCID:
PMC4066738
DOI:
10.1038/jid.2011.425
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center