Format

Send to

Choose Destination
See comment in PubMed Commons below
J Invest Dermatol. 2012 Mar;132(3 Pt 2):949-63. doi: 10.1038/jid.2011.435. Epub 2012 Jan 5.

Skin barrier disruption: a requirement for allergen sensitization?

Author information

1
Department of Dermatology, University of Rochester Medical Center, Rochester, New York 14642, USA.

Abstract

For at least half a century, noninvasive techniques have been available to quantify skin barrier function, and these have shown that a number of human skin conditions and disorders are associated with defects in skin permeability. In the past decade, several genes responsible for skin barrier defects observed in both monogenetic and complex polygenic disorders have been elucidated and functionally characterized. This has led to an explosion of work in the past 6 years that has identified pathways connecting epidermal barrier disruption and antigen uptake, as well as the quality and/or magnitude of the antigen-specific adaptive immune response. This review will introduce the notion that diseases arise from the dynamic crosstalk that occurs between skin barrier and the immune system using atopic dermatitis or eczema as the disease prototype. Nevertheless, the concepts put forth are highly relevant to a number of antigen-driven disorders for which skin barrier is at least transiently compromised, such as psoriasis, allergic contact dermatitis, and blistering disorders.

PMID:
22217737
PMCID:
PMC3279586
DOI:
10.1038/jid.2011.435
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science Icon for PubMed Central
    Loading ...
    Support Center