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Curr Opin Neurobiol. 2012 Jun;22(3):461-9. doi: 10.1016/j.conb.2011.12.006. Epub 2012 Jan 2.

Regulation of AMPA receptor trafficking and synaptic plasticity.

Author information

1
Department of Neuroscience, Howard Hughes Medical Institute, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, United States.

Abstract

AMPA receptors (AMPARs) mediate the majority of fast excitatory synaptic transmission in the brain. Dynamic changes in neuronal synaptic efficacy, termed synaptic plasticity, are thought to underlie information coding and storage in learning and memory. One major mechanism that regulates synaptic strength involves the tightly regulated trafficking of AMPARs into and out of synapses. The life cycle of AMPARs from their biosynthesis, membrane trafficking, and synaptic targeting to their degradation are controlled by a series of orchestrated interactions with numerous intracellular regulatory proteins. Here we review recent progress made toward the understanding the regulation of AMPAR trafficking, focusing on the roles of several key intracellular AMPAR interacting proteins.

PMID:
22217700
PMCID:
PMC3392447
DOI:
10.1016/j.conb.2011.12.006
[Indexed for MEDLINE]
Free PMC Article

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