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Psychiatry Investig. 2011 Dec;8(4):372-6. doi: 10.4306/pi.2011.8.4.372. Epub 2011 Dec 8.

Electroencephalographic abnormalities in clozapine-treated patients: a cross-sectional study.

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Senior Resident, Centre for Cognitive Neurosciences, Central Institute of Psychiatry, Kanke, Ranchi, Jharkhand, India.


The objective of our study was to examine the electroencephalogram (EEG) abnormalities associated with clozapine treatment. It was a cross-sectional study on 87 psychiatric patients on clozapine treatment. 32 channel digital EEG was recorded and analysed visually for abnormalities. EEG abnormalities were observed in 63.2% of patients. Both slowing and epileptiform activities were noted in 41.4% of patients. The EEG abnormalities were not associated with dose or duration of clozapine exposure.


Clozapine; EEG abnormalities; Seizures

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