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Genes Dev. 2012 Jan 1;26(1):31-6. doi: 10.1101/gad.177436.111.

Polyploidization of glia in neural development links tissue growth to blood-brain barrier integrity.

Author information

1
Whitehead Institute, Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA.

Abstract

Proper development requires coordination in growth of the cell types composing an organ. Many plant and animal cells are polyploid, but how these polyploid tissues contribute to organ growth is not well understood. We found the Drosophila melanogaster subperineurial glia (SPG) to be polyploid, and ploidy is coordinated with brain mass. Inhibition of SPG polyploidy caused rupture of the septate junctions necessary for the blood-brain barrier. Thus, the increased SPG cell size resulting from polyploidization is required to maintain the SPG envelope surrounding the growing brain. Polyploidization likely is a conserved strategy to coordinate tissue growth during organogenesis, with potential vertebrate examples.

PMID:
22215808
PMCID:
PMC3258963
DOI:
10.1101/gad.177436.111
[Indexed for MEDLINE]
Free PMC Article

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