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J Dermatolog Treat. 2013 Aug;24(4):300-4. doi: 10.3109/09546634.2011.649690. Epub 2012 Jan 31.

An open, comparative study of 10% potassium hydroxide solution versus salicylic and lactic acid combination in the treatment of molluscum contagiosum in children.

Author information

1
Department of Dermatology, Gulhane School of Medicine, Ankara, Turkey. okose@gata.edu.tr

Abstract

OBJECTIVES:

To evaluate and compare the safety and efficacy of 10% potassium hydroxide (KOH) solution and salicylic and lactic acid (SAL + LAC) combination in the treatment of molluscum contagiosum (MC).

MATERIAL AND METHODS:

26 patients with MC randomized into two treatment groups. 12 patients treated with 10% KOH solution and 14 patients treated with SAL + LAC combination for 6 weeks. Parents of patients were instructed to apply medication once daily only to lesions at study onset. Assessment of response of the treated lesions and side effects was performed at 2, 4 and 6 weeks of the treatment. Newly acquired lesions were not included in the study.

RESULTS:

At the end of therapy, 83.3% (n = 10) of KOH group demonstrated complete remission and 16.7% (n = 2) of them showed partial remission; four patients (33%) developed new lesions during the study. All the patients in the SAL + LAC combination group (100%) demonstrated complete remission of study entry lesions at the end of 6 weeks with five patients (35%) acquiring new lesions during the study. Minor side effects were observed in two groups.

CONCLUSIONS:

10% KOH solution and SAL + LAC combination were found to be equally effective in the treatment of MC in children.

PMID:
22214282
DOI:
10.3109/09546634.2011.649690
[Indexed for MEDLINE]

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