Format

Send to

Choose Destination
J Cell Biol. 2012 Jan 9;196(1):65-83. doi: 10.1083/jcb.201106088. Epub 2012 Jan 2.

dEHBP1 controls exocytosis and recycling of Delta during asymmetric divisions.

Author information

1
Howard Hughes Medical Institute, Baylor College of Medicine, Houston, TX 77030, USA.

Abstract

Notch signaling governs binary cell fate determination in asymmetrically dividing cells. Through a forward genetic screen we identified the fly homologue of Eps15 homology domain containing protein-binding protein 1 (dEHBP1) as a novel regulator of Notch signaling in asymmetrically dividing cells. dEHBP1 is enriched basally and at the actin-rich interface of pII cells of the external mechanosensory organs, where Notch signaling occurs. Loss of function of dEHBP1 leads to up-regulation of Sanpodo, a regulator of Notch signaling, and aberrant trafficking of the Notch ligand, Delta. Furthermore, Sec15 and Rab11, which have been previously shown to regulate the localization of Delta, physically interact with dEHBP1. We propose that dEHBP1 functions as an adaptor molecule for the exocytosis and recycling of Delta, thereby affecting cell fate decisions in asymmetrically dividing cells.

PMID:
22213802
PMCID:
PMC3255984
DOI:
10.1083/jcb.201106088
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for HighWire Icon for PubMed Central
Loading ...
Support Center