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Cancer Sci. 2012 Apr;103(4):626-31. doi: 10.1111/j.1349-7006.2011.02195.x. Epub 2012 Jan 29.

Behavior of seeds and soil in the mechanism of metastasis: a deeper understanding.

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Uppsala University, Uppsala, Sweden. lucy.mathot@igp.uu.se

Abstract

The so-called "seed and soil" hypothesis proposed by Stephen Paget in 1889 to explain the metastatic behavior of cancer cells and the homing of certain cancers to "selected" sites has been a well-recognized phenomenon for over a century. What advances have been made to increase our understanding of this phenomenon and what does it really implicate in terms of targets for therapy?

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