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Ann N Y Acad Sci. 2011 Dec;1245:50-4. doi: 10.1111/j.1749-6632.2011.06310.x.

Humanized mice as a preclinical tool for infectious disease and biomedical research.

Author information

1
The Jackson Laboratory, Bar Harbor, Maine, USA. lenny.shultz@jax.org

Abstract

Immunodeficient mice bearing an IL2rγ(null) mutation permit engraftment of a functional human immune system and study of human-specific infectious agents that was not previously possible.

PMID:
22211979
PMCID:
PMC3514446
DOI:
10.1111/j.1749-6632.2011.06310.x
[Indexed for MEDLINE]
Free PMC Article

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