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J Biol Phys. 2011 Jan;37(1):153-61. doi: 10.1007/s10867-010-9206-4. Epub 2010 Oct 30.

pH effect on cellular uptake of Sn(IV) chlorine e6 dichloride trisodium salt by cancer cells in vitro.

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1
School of Physics, Universiti Sains Malaysia, 11800 Penang, Malaysia.

Abstract

The effects of pH value and presence of serum in an incubation medium on photosensitizer drug cellular uptake in MCF7 cancer cells have been investigated. The results showed that the presence of serum in an incubation medium reduced the drug cellular uptake at all pH values. It has been found that decreasing on pH values of the incubation medium increased the cellular uptake of the drug, demonstrating selective uptake of the sensitizer. The HepG2 liver cancer cells exhibited more drug cellular uptake than CCD-18CO normal colon cells, which assessed the selectivity uptake of photosensitizer on cancerous cells. The concentration of photosensitizer measured in 10(6) cells showed a good correlation to the incubation time. Fluorescence and absorption spectroscopy been have used to examine the cells.

KEYWORDS:

Cellular uptake; Photodynamic therapy; Sn(IV) chlorin e6

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