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Mol Biol Cell. 2012 Jan;23(1):7-11. doi: 10.1091/mbc.E11-06-0512.

Polarity sets the stage for cytokinesis.

Author information

1
Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA. stephen.doxsey@umassmed.edu

Abstract

Cell polarity is important for a number of processes, from chemotaxis to embryogenesis. Recent studies suggest a new role for polarity in the orchestration of events during the final cell separation step of cell division called abscission. Abscission shares several features with cell polarization, including rearrangement of phosphatidylinositols, reorganization of microtubules, and trafficking of exocyst-associated membranes. Here we focus on how the canonical pathways for cell polarization and cell migration may play a role in spatiotemporal membrane trafficking events required for the final stages of cytokinesis.

PMID:
22210846
PMCID:
PMC3248905
DOI:
10.1091/mbc.E11-06-0512
[Indexed for MEDLINE]
Free PMC Article

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