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AIDS. 2012 Mar 13;26(5):643-6. doi: 10.1097/QAD.0b013e3283509a0b.

Cellular immune responses and susceptibility to HIV-1 superinfection: a case-control study.

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1
Division of Human Biology, Fred Hutchinson Cancer Research Center, University of Washington, Seattle, Washington, USA. cblish@stanford.edu

Abstract

A case-control study was performed to determine the effects of HIV-1-specific cellular immune responses on the odds of acquiring a second HIV-1 infection (superinfection). Changes in the frequency of cytokine-producing or cytolytic CD8+ or CD4+ T cells were not associated with significant alterations in the odds of superinfection, suggesting that HIV-1 specific cellular immune responses at the level induced by chronic infection do not appear to significantly contribute to protection from HIV-1 superinfection.

PMID:
22210637
PMCID:
PMC3511787
DOI:
10.1097/QAD.0b013e3283509a0b
[Indexed for MEDLINE]
Free PMC Article
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