Antibacterial activities of dendritic amphiphiles against nontuberculous mycobacteria

Tuberculosis (Edinb). 2012 Mar;92(2):173-81. doi: 10.1016/j.tube.2011.12.002. Epub 2011 Dec 30.

Abstract

The anti-mycobacterial activities of nine series of dicarboxyl and tricarboxyl dendritic amphiphiles with one alkyl, two alkyl, and cholestanyl tails against Mycobacterium abscessus, Mycobacterium avium, Mycobacterium chelonae, Mycobacterium marinum and Mycobacterium smegmatis have been measured. The dendritic amphiphiles overcame the limited aqueous solubility of natural long-chain fatty acids, alcohols, and amines to enable profiling the susceptibilities of the different mycobacterial species to the physicochemical properties of these amphiphiles. Several dendritic amphiphiles showed strong anti-mycobacterial activity with high critical micelle concentrations and low hemolytic activities thereby offering platforms for the development of antibiotics of higher activity against nontuberculous mycobacteria.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / chemistry
  • Anti-Bacterial Agents / pharmacology*
  • Biofilms / drug effects
  • Dendrimers / chemistry
  • Dendrimers / pharmacology*
  • Drug Evaluation, Preclinical / methods
  • Drug Resistance, Bacterial
  • Hemolysis / drug effects
  • Humans
  • Membrane Fluidity / drug effects
  • Micelles
  • Microbial Sensitivity Tests / methods
  • Mycobacterium avium / drug effects
  • Mycobacterium avium / growth & development
  • Mycobacterium avium / physiology
  • Nontuberculous Mycobacteria / classification
  • Nontuberculous Mycobacteria / drug effects*
  • Nontuberculous Mycobacteria / growth & development
  • Nontuberculous Mycobacteria / physiology
  • Species Specificity
  • Structure-Activity Relationship
  • Temperature

Substances

  • Anti-Bacterial Agents
  • Dendrimers
  • Micelles