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Rev Med Interne. 2012 Feb;33(2):87-93. doi: 10.1016/j.revmed.2011.11.010. Epub 2011 Dec 28.

[Vitamin D and autoimmunity. Second part: Clinical aspects].

[Article in French]

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  • 1Service de médecine interne, université Versailles-Saint-Quentin-en-Yvelines, hôpital Foch, 40, rue Worth, 92151 Suresnes cedex, France.


Vitamin D is often confined to its role in calcium homeostasis and bone metabolism. An exponential literature discusses its non-skeletal effects, especially its central role in the physiology of the immune system, where it acts at several levels to maintain self-tolerance. Here, the authors review the experimental, epidemiological and clinical studies, illustrating the potential role of vitamin D in the development and perpetuation of autoimmune diseases such as systemic lupus erythematosus, type 1 diabetes mellitus, multiple sclerosis, inflammatory bowel diseases or rheumatoid arthritis.

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