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Mol Cells. 2011 Dec;32(6):491-509. doi: 10.1007/s10059-011-0276-3. Epub 2011 Dec 22.

Regulation of reactive oxygen species generation in cell signaling.

Author information

1
Department of Life Science, Division of Life and Pharmaceutical Sciences, Ewha Womans University, Seoul 120-750, Korea. baeys@ewha.ac.kr

Abstract

Reactive oxygen species (ROS) including superoxide anion and hydrogen peroxide (H(2)O(2)) are thought to be byproducts of aerobic respiration with damaging effects on DNA, protein, and lipid. A growing body of evidence indicates, however, that ROS are involved in the maintenance of redox homeostasis and various cellular signaling pathways. ROS are generated from diverse sources including mitochondrial respiratory chain, enzymatic activation of cytochrome p450, and NADPH oxidases further suggesting involvement in a complex array of cellular processes. This review summarizes the production and function of ROS. In particular, how cytosolic and membrane proteins regulate ROS generation for intracellular redox signaling will be detailed.

PMID:
22207195
PMCID:
PMC3887685
DOI:
10.1007/s10059-011-0276-3
[Indexed for MEDLINE]
Free PMC Article

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