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Microbes Infect. 2012 May;14(5):392-400. doi: 10.1016/j.micinf.2011.12.005. Epub 2011 Dec 17.

Anthrax and the inflammasome.

Author information

1
Laboratory of Bacterial Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. mmoayeri@niaid.nih.gov

Abstract

Anthrax lethal toxin (LT), a major virulence determinant of anthrax disease, induces vascular collapse in mice and rats. LT activates the Nlrp1 inflammasome in macrophages and dendritic cells, resulting in caspase-1 activation, IL-1β and IL-18 maturation and a rapid cell death (pyroptosis). This review presents the current understanding of LT-induced activation of Nlrp1 in cells and its consequences for toxin-mediated effects in rodent toxin and spore challenge models.

PMID:
22207185
PMCID:
PMC3322314
DOI:
10.1016/j.micinf.2011.12.005
[Indexed for MEDLINE]
Free PMC Article

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