Format

Send to

Choose Destination
See comment in PubMed Commons below
Curr Opin Microbiol. 2012 Feb;15(1):44-9. doi: 10.1016/j.mib.2011.12.002. Epub 2011 Dec 27.

Group B Streptococcus surface proteins as major determinants for meningeal tropism.

Author information

1
Institut Cochin, Université Paris Descartes Sorbonne Paris Cité, CNRS (UMR 8104), Paris, France.

Abstract

Streptococcus agalactiae (group B Streptococcus, GBS), a normal constituent of the intestinal microbiota is the major cause of human neonatal infections and a worldwide spread 'hypervirulent' clone, GBS ST-17, is strongly associated with neonatal meningitis. Adhesion to epithelial and endothelial cells constitutes a key step of the infectious process. Therefore GBS surface-anchored proteins are obvious potential adhesion mediators of barrier crossing and determinant of hypervirulence. This review addresses the most recent molecular insights gained from studies on GBS surface proteins proven to be involved in the crossing of the brain-blood barrier and emphasizes on the specificity of a hypervirulent clone that displays meningeal tropism.

PMID:
22206860
DOI:
10.1016/j.mib.2011.12.002
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center