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Curr Drug Targets. 2012 Mar;13(3):373-87.

Screening strategies to identify new antibiotics.

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1
Division of Chemistry and Structural Biology, Institute for Molecular Bioscience, The University of Queensland, St. Lucia, Brisbane, 4072, Australia.

Abstract

The emergence of multi-drug resistant bacteria is one of the most critical medical problems currently facing humankind, which will only get worse if no new antibacterial drugs are launched. This article will first review commonly used screening strategies used to identify potential new antibiotics and then discuss novel screening methods. In addition, new assays, methods, biological targets and compounds with novel modes of action undergoing pre-clinical or clinical development are briefly discussed.

PMID:
22206258
[Indexed for MEDLINE]
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