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Curr Drug Targets. 2012 Mar;13(3):432-9.

CD248: reviewing its role in health and disease.

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1
Division of Hematology, Department of Medicine, Centre for Blood Research, University of British Columbia, Vancouver, British Columbia, Canada.

Abstract

CD248, also known as endosialin or tumor endothelial marker-1 (TEM-1), is a C-type lectin-like domain (CTLD) containing cell surface glycoprotein that is expressed by stromal cells of proliferating tissues during embryogenesis and postnatally in tumors and inflammatory lesions. Loss-of-function studies in mice support the notion that CD248 promotes tumor growth and inflammation, observations that are stimulating interest in evaluating this molecule as a therapeutic target. In spite of these advances, the mechanisms by which CD248 modulates cancer and inflammation remain largely enigmatic. This review highlights our current understanding of CD248, its structure, pattern of expression, regulation and function in various disease processes.

PMID:
22206249
[Indexed for MEDLINE]

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