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J Clin Microbiol. 2012 Apr;50(4):1449-51. doi: 10.1128/JCM.06212-11. Epub 2012 Jan 11.

Individual Plasmodium vivax msp1 variants within polyclonal P. vivax infections display different propensities for relapse.

Author information

1
Division of Infectious Diseases, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA. jessica_lin@med.unc.edu

Abstract

Using a newly developed Plasmodium vivax merozoite surface protein 1 gene (Pvmsp1) heteroduplex tracking assay, we genotyped 107 P. vivax infections in individuals from Cambodia, 45 of whom developed recurrent parasitemia within 42 days. The majority of isolates were polyclonal, but recurrent parasitemias displayed fewer variants compared to initial parasitemias. Two Pvmsp1 gene variants occurred more frequently in the initial genotypes of those who developed recurrent parasitemia, representing the first time P. vivax variants associated with a higher risk of relapse have been described.

PMID:
22205791
PMCID:
PMC3318509
DOI:
10.1128/JCM.06212-11
[Indexed for MEDLINE]
Free PMC Article

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