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Am J Physiol Endocrinol Metab. 2012 Mar 1;302(5):E496-9. doi: 10.1152/ajpendo.00578.2011. Epub 2011 Dec 28.

A perspective on the determination of mitochondrial biogenesis.

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1
Dept. of Health and Exercise Science, Colorado State University, Fort Collins, CO 80523-1582, USA. Benjamin.f.miller@colostate.edu

Abstract

The measurement of mitochondrial biogenesis is important in the determination of aging and disease processes and the assessment of countermeasurements to them. We argue that the frequently used assessments of cell signaling, mitochondrial protein mRNA, mitochondrial protein expression or enzyme activity, and mitochondrial density are not measurements that can lead to conclusions about mitochondrial biogenesis. Instead, we propose that only measurements of mitochondrial synthesis are indicative of biogenesis. Clarification of this issue will hopefully result in further differentiation of the processes important for morphological and functional changes of mitochondria.

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PMID:
22205627
PMCID:
PMC3311289
DOI:
10.1152/ajpendo.00578.2011
[Indexed for MEDLINE]
Free PMC Article
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