Send to

Choose Destination
N Engl J Med. 2012 Feb 23;366(8):715-22. doi: 10.1056/NEJMoa1111432. Epub 2011 Dec 28.

Three patients with full facial transplantation.

Author information

Department of Surgery, Division of Plastic Surgery, Brigham and Women's Hospital, Boston, MA 02115, USA.


Unlike conventional reconstruction, facial transplantation seeks to correct severe deformities in a single operation. We report on three patients who received full-face transplants at our institution in 2011 in operations that aimed for functional restoration by coaptation of all main available motor and sensory nerves. We enumerate the technical challenges and postoperative complications and their management, including single episodes of acute rejection in two patients. At 6 months of follow-up, all facial allografts were surviving, facial appearance and function were improved, and glucocorticoids were successfully withdrawn in all patients.

[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Atypon
Loading ...
Support Center